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Comment
. 2014 Apr 17;40(4):451-2.
doi: 10.1016/j.immuni.2014.04.005.

The emerging landscape of RORγt biology

Jacob S Lee  1 , Daniel J Cua  2
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Free article
Comment

The emerging landscape of RORγt biology

Jacob S Lee et al. Immunity. .
Free article

Abstract

The transcription factor retinoid-related orphan receptor gamma t (RORγt) has emerged as an exciting target for inflammatory diseases. Xiao et al. (2014) show that a new class of RORγt antagonists can inhibit the inflammatory function of T helper 17 cells without altering RORγt occupancy on its target genes.

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