Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 May 21;588(10):1879-85.
doi: 10.1016/j.febslet.2014.04.008. Epub 2014 Apr 18.

Crystal structure of FtsA from Staphylococcus aureus

Junso Fujita  1 , Yoko Maeda  1 , Chioko Nagao  2 , Yuko Tsuchiya  2 , Yuma Miyazaki  1 , Mika Hirose  3 , Eiichi Mizohata  1 , Yoshimi Matsumoto  4 , Tsuyoshi Inoue  1 , Kenji Mizuguchi  2 , Hiroyoshi Matsumura  5
Affiliations
Free article

Crystal structure of FtsA from Staphylococcus aureus

Junso Fujita et al. FEBS Lett. .
Free article

Abstract

The bacterial cell-division protein FtsA anchors FtsZ to the cytoplasmic membrane. But how FtsA and FtsZ interact during membrane division remains obscure. We have solved 2.2 Å resolution crystal structure for FtsA from Staphylococcus aureus. In the crystals, SaFtsA molecules within the dimer units are twisted, in contrast to the straight filament of FtsA from Thermotoga maritima, and the half of S12-S13 hairpin regions are disordered. We confirmed that SaFtsZ and SaFtsA associate in vitro, and found that SaFtsZ GTPase activity is enhanced by interaction with SaFtsA.

Keywords: Bacterial divisome; FtsA; FtsZ; Staphylococcus aureus.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources