[The influence of truncal vagotomy or surgical sympathectomy on the pancreatic trophic effect of trypsin inhibitor upon normal rats and major pancreatectomized rats]

Abstract

The influences of truncal vagotomy or surgical sympathectomy on the pancreatic trophic effect of oral administration of synthetic trypsin inhibitor (FOY-305) were examined upon normal rats and 85% major pancreatectomized rats. On normal rats, oral administration of trypsin inhibitor increased pancreatic weight, DNA content RNA content, protein content, pancreatic weight/DNA, RNA/DNA and protein/DNA. This pancreatic trophic effect seemed to be consisted of hyperplasia and hypertrophy of pancreatic acinar cell. Under truncal vagotomy or surgical sympathectomy, this trophic effect was not diminished. On major pancreatectomized rats, oral administration of trypsin inhibitor also caused pancreatic trophic action, consisted of hyperplasia mainly. And truncal vagotomy or surgical sympathectomy did not decrease this action. These results suggested that oral administration of trypsin inhibitor might be a beneficial method for functional recovery of remnant pancreas after major pancreatectomy even under the denervated state.