Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Jun;9(6):2761-4.
doi: 10.1128/mcb.9.6.2761-2764.1989.

Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers

D Shippen-Lentz  1 , E H Blackburn
Affiliations

Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers

D Shippen-Lentz et al. Mol Cell Biol. 1989 Jun.

Abstract

A telomere terminal transferase activity was identified in developing macronuclear extracts from Euplotes crassus. The activity was essentially unregulated in vitro: up to 50 tandem repeats of the Euplotes telomeric repeat sequence TTTTGGGG were added onto synthetic telomeric oligonucleotide primers. Both the structure of the telomere substrate and its 3'-terminal sequence were recognized. The activity was destroyed by low concentrations of RNase A.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1981 May;78(5):3015-9 - PubMed
    1. Nucleic Acids Res. 1982 Dec 20;10(24):8145-54 - PubMed
    1. Cell. 1984 May;37(1):7-8 - PubMed
    1. Nature. 1984 Jul 12-18;310(5973):154-7 - PubMed
    1. Annu Rev Biochem. 1984;53:163-94 - PubMed

Publication types

LinkOut - more resources