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. 1989 Aug;86(16):6293-6.
doi: 10.1073/pnas.86.16.6293.

A third T-cell receptor beta-chain variable region gene encodes reactivity to Mls-1a gene products

M P Happ  1 , D L Woodland, E Palmer
Affiliations

A third T-cell receptor beta-chain variable region gene encodes reactivity to Mls-1a gene products

M P Happ et al. Proc Natl Acad Sci U S A. 1989 Aug.

Abstract

Using a quantitative RNA hybridization method, we have identified a third murine T-cell receptor beta-chain variable (V) region gene, V beta 9, that engenders recognition of Mls-1a gene products. V beta 9-expressing T cells are clonally deleted from the periphery of mice that carry the Mls-1a allele, and the fine specificity of V beta 9+ hybridomas suggests that V beta 6-, V beta 8.1-, and V beta 9-encoded T-cell receptors may recognize a similar antigenic epitope. Comparison of these three protein sequences identifies two residues that may be important in determining this recognition specificity.

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