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. 2014 May;20(5):799-805.
doi: 10.3201/eid2005.130142.

Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae clone

Debby Ben-David, Mitchell J Schwaber, Amos Adler, Samira Masarwa, Rotem Edgar, Shiri Navon-Venezia, David Schwartz, Nurith Porat, Tali Kotlovsky, Nikolay Polivkin, Irina Weinberg, Avraham Lazary, Nissim Ohana, Ron Dagan

Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae clone

Debby Ben-David et al. Emerg Infect Dis. 2014 May.

Abstract

Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone-resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.

Keywords: Streptococcus pneumoniae; antimicrobial drug resistance; bacteria; clonal evolution; fluoroquinolones; long-term acute care hospital.

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Figures

Figure 1
Figure 1
Serotyping and clonal analysis of the first point-prevalence survey of Streptococcus pneumoniae infection in a post–acute care facility, Israel, 2006–2011. FQ fluoroquinolone; ST, sequence type; FQISP, fluoroquinolone-intermediate S. pneumoniae; FQRSP fluoroquinolone-resistant S. pneumoniae.
Figure 2
Figure 2
Clinical isolates of FQ-resistant Streptococcus pneumoniae in a post–acute care facility, Israel, 2006–2011. FQ, fluoroquinolone.
See this image and copyright information in PMC

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