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Review
. 2014 Jun;29(7):857-67.
doi: 10.1002/mds.25880. Epub 2014 Apr 18.

Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group

Iva Stankovic  1 , Florian Krismer, Aleksandar Jesic, Angelo Antonini, Thomas Benke, Richard G Brown, David J Burn, Janice L Holton, Horacio Kaufmann, Vladimir S Kostic, Helen Ling, Wassilios G Meissner, Werner Poewe, Marija Semnic, Klaus Seppi, Atsushi Takeda, Daniel Weintraub, Gregor K Wenning; Movement Disorders Society MSA (MODIMSA) Study Group
Affiliations
Review

Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group

Iva Stankovic et al. Mov Disord. 2014 Jun.

Abstract

Consensus diagnostic criteria for multiple system atrophy consider dementia as a nonsupporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal-executive dysfunction is the most common presentation, while memory and visuospatial functions also may be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation, with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidence-based review, the authors propose future avenues of research that ultimately may lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy.

Keywords: cognition; multiple system atrophy; neuropsychology.

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References

    1. Wenning GK, Tison F, Ben Shlomo Y, Daniel SE, Quinn NP. Multiple system atrophy: a review of 203 pathologically proven cases. Movement disorders : official journal of the Movement Disorder Society. 1997;12(2):133–147. - PubMed
    1. Gilman S, Wenning GK, Low PA, et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology. 2008;71(9):670–676. - PMC - PubMed
    1. Brown RG, Lacomblez L, Landwehrmeyer BG, et al. Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy. Brain : a journal of neurology. 2010;133(Pt 8):2382–2393. - PubMed
    1. Gilman S, May SJ, Shults CW, et al. The North American Multiple System Atrophy Study Group. J Neural Transm. 2005;112(12):1687–1694. - PubMed
    1. Kawamura K, Shimohata T, Nakayama H, Tomita M, Ozawa T, Nishizawa M. Factors influencing the cognitive function in patients with multiple system atrophy. Movement disorders : official journal of the Movement Disorder Society. 2010;25(16):2891–2892. - PubMed

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