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Review
. 2014 Apr;47(4):192-6.
doi: 10.5483/bmbrep.2014.47.4.060.

The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1

Harikrishna Reddy R  1 , Hackyoung Kim  1 , Kwangmo Noh  2 , Young Jun Kim  3
Affiliations
Review

The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1

Harikrishna Reddy R et al. BMB Rep. 2014 Apr.

Abstract

RNA polymerase II carboxyl-terminal domain (pol II CTD) phosphatases are a newly emerging family of phosphatases that are members of DXDX (T/V). The subfamily includes Small CTD phosphatases, like SCP1, SCP2, SCP3, TIMM50, HSPC129 and UBLCP. Extensive study of SCP1 has elicited the diversified roles of the small C terminal domain phosphatase. The SCP1 plays a vital role in various biological activities, like neuronal gene silencing and preferential Ser5 dephosphorylation, acts as a cardiac hypertrophy inducer with the help of its intronic miRNAs, and has shown a key role in cell cycle regulation. This short review offers an explanation of the mechanism of action of small CTD phosphatases, in different biological activities and metabolic processes.

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Figures

Fig. 1.
Fig. 1.. SCP1 related signaling pathways.
See this image and copyright information in PMC

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