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Practice Guideline
. 2014 Jul;118(3):479-88.
doi: 10.1007/s11060-013-1336-7. Epub 2014 Apr 23.

The role of cytoreductive surgery in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline

Timothy Charles Ryken  1 , Steven N Kalkanis, John M Buatti, Jeffrey J Olson; AANS/CNS Joint Guidelines Committee
Affiliations
Practice Guideline

The role of cytoreductive surgery in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline

Timothy Charles Ryken et al. J Neurooncol. 2014 Jul.

Abstract

Question: Should patients with previously diagnosed malignant glioma who are suspected of experiencing progression of the neoplasm process undergo repeat open surgical resection?

Target population: These recommendations apply to adults with previously diagnosed malignant glioma who are suspected of experiencing progression of the neoplastic process and are amenable to surgical resection.

Recommendations level ii: Repeat cytoreductive surgery is recommended in symptomatic patients with locally recurrent or progressive malignant glioma. The median survival in these patient diagnosed with glioblastoma is expected to range from 6 to 17 months following a second procedure. It is recommended that the following preoperative factors be considered when evaluating a patient for repeat operation: location of recurrence in eloquent/critical brain regions, Karnofsky Performance Status and tumor volume.

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