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Review
. 2014:222:293-319.
doi: 10.1007/978-3-642-54215-2_12.

The TRPV4 channel

Anna Garcia-Elias  1 , Sanela Mrkonjić, Carole Jung, Carlos Pardo-Pastor, Rubén Vicente, Miguel A Valverde
Affiliations
Review

The TRPV4 channel

Anna Garcia-Elias et al. Handb Exp Pharmacol. 2014.

Abstract

The widely distributed TRPV4 cationic channel participates in the transduction of both physical (osmotic, mechanical, and heat) and chemical (endogenous, plant-derived, and synthetic ligands) stimuli. In this chapter we will review TRPV4 expression, biophysics, structure, regulation, and interacting partners as well as physiological and pathological insights obtained in TRPV4 animal models and human genetic studies.

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