Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014:222:521-46.
doi: 10.1007/978-3-642-54215-2_21.

TRPM7

Andrea Fleig  1 , Vladimir Chubanov
Affiliations
Review

TRPM7

Andrea Fleig et al. Handb Exp Pharmacol. 2014.

Abstract

The channel kinases TRPM6 and TRPM7 are fusion proteins with an ion transport domain and an enzymatically active kinase domain. TRPM7 has been found in every mammalian tissue investigated to date. The two-in-one protein structure, the ubiquitous expression profile, and the protein's unique biophysical characteristics that enable divalent ion transport involve TRPM7 in a plethora of (patho)physiological processes. With its prominent role in cellular and systemic magnesium homeostasis, TRPM7 emerges as a key player in embryonic development, global ischemia, cardiovascular disease, and cancer.

PubMed Disclaimer

References

    1. Aarts M, Iihara K, Wei WL, Xiong ZG, Arundine M, Cerwinski W, MacDonald JF, Tymianski M. A key role for TRPM7 channels in anoxic neuronal death. Cell. 2003;115(7):863–877. - PubMed
    1. Abed E, Moreau R. Importance of melastatin-like transient receptor potential 7 and cations (magnesium, calcium) in human osteoblast-like cell proliferation. Cell Prolif. 2007;40(6):849–865. doi: 10.1111/j.1365-2184.2007.00476.x. - DOI - PMC - PubMed
    1. Bessac BF, Fleig A. TRPM7 channel is sensitive to osmotic gradients in human kidney cells. J Physiol. 2007;582(Pt 3):1073–1086. doi: 10.1113/jphysiol.2007.130534. - DOI - PMC - PubMed
    1. Cahalan MD, Lewis RS. Role of potassium and chloride channels in volume regulation by T lymphocytes. Soc Gen Physiol Ser. 1988;43:281–301. - PubMed
    1. Castillo B, Porzgen P, Penner R, Horgen FD, Fleig A. Development and optimization of a high-throughput bioassay for TRPM7 ion channel inhibitors. J Biomol Screen. 2010;15(5):498–507. doi: 10.1177/1087057110368294. - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources