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Meta-Analysis
. 2014 Jul;35(7):7073-7.
doi: 10.1007/s13277-014-1951-8. Epub 2014 Apr 23.

Association of periodontal disease with oral cancer: a meta-analysis

Qi-Wei Yao  1 , Dong-Sheng Zhou, Hong-Juan Peng, Ping Ji, De-Sheng Liu
Affiliations
Free article
Meta-Analysis

Association of periodontal disease with oral cancer: a meta-analysis

Qi-Wei Yao et al. Tumour Biol. 2014 Jul.
Free article

Abstract

The objective is to evaluate the association of periodontal disease with the risk of oral cancer. Literature retrieval, selection and assessment, data extraction, and meta-analyses were performed according to the RevMan 5.0 guidelines. In the meta-analysis, we utilized random-effect model to pool the odds ratio (OR) according to the test of heterogeneity. A total of five eligible studies included 1,191 oral cancer patients and 1,992 healthy control subjects were analyzed. By meta-analysis, we found a significant association of periodontal disease with oral cancer [OR = 3.53, 95 % CI (1.52-8.23); P = 0.003]. Patients with periodontal disease have increased susceptibility to oral cancer.

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