Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 May 19;53(21):5435-9.
doi: 10.1002/anie.201402788. Epub 2014 Apr 22.

Highly diastereo- and enantioselective silver-catalyzed double [3+2] cyclization of α-imino esters with isocyanoacetate

Pan-Lin Shao  1 , Jia-Yu Liao, Yee Ann Ho, Yu Zhao
Affiliations

Highly diastereo- and enantioselective silver-catalyzed double [3+2] cyclization of α-imino esters with isocyanoacetate

Pan-Lin Shao et al. Angew Chem Int Ed Engl. .

Abstract

Presented herein is a new complexity-generating method in which both functionalities of α-imino esters undergo stereoselective cyclization with isocyanoacetates to produce directly linked oxazole-imidazolines, which can be transformed into highly functionalized α,β-diamino esters and imidazolinium salts in high diastereo- and enantiopurity.

Keywords: asymmetric catalysis; cyclization; enantioselectivity; heterocycles; multicomponent reaction.

PubMed Disclaimer

Publication types

LinkOut - more resources