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. 2014 Apr 22;111(16):5758-9.
doi: 10.1073/pnas.1404819111.

The RNA code: nature's Rosetta Stone

C Thomas Caskey  1 , Philip Leder
Affiliations

The RNA code: nature's Rosetta Stone

C Thomas Caskey et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

None
Heinrich Matthaei (Left) and Marshall Nirenberg (Right) collaborated in the now classic experiment demonstrating protein synthesis from synthetic poly-U that provided the initial clue to breaking the genetic code. This photograph was taken circa 1962 as they continued to decipher additional elements of the code. (Courtesy of Marshall W. Nirenberg from the National Library of Medicine).
See this image and copyright information in PMC

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References

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    1. Crick FH, Barnett L, Brenner S, Watts-Tobin RJ. General nature of the genetic code for proteins. Nature. 1961;192:1227–1232. - PubMed
    1. Nirenberg MW, Matthaei JH. The dependence of cell-free protein synthesis in E. coli upon naturally occurring or synthetic polyribonucleotides. Proc Natl Acad Sci USA. 1961;47:1588–1602. - PMC - PubMed
    1. Martin RG, Matthaei JH, Jones OW, Nirenberg MW. Ribonucleotide composition of the genetic code. Biochem Biophys Res Commun. 1962;6:410–414. - PubMed
    1. Nirenberg M, Leder P. RNA codewords and protein synthesis: The effect of trinucleotides upon the binding of sRNA to ribosomes. Science. 1964;145(3639):1399–1407. - PubMed

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