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Comment
. 2014 May;63(5):1448-50.
doi: 10.2337/db14-0003.

Amyloid and the macrophage: it's all about local production of IL-1β

Katarzyna A Broniowska  1 , John A Corbett
Affiliations
Comment

Amyloid and the macrophage: it's all about local production of IL-1β

Katarzyna A Broniowska et al. Diabetes. 2014 May.
No abstract available

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Figures

Figure 1
Figure 1
Intraislet macrophage activation and β-cell damage. Westwell-Roper et al. (14) provide evidence that IAPP damages β-cells (yellow) by a mechanism that is associated with resident islet macrophage (black) activation and the local release of IL-1β within islets to levels sufficient to damage β-cells. This pathway is consistent with previous studies showing that macrophage activators (TNF + LPS, rat; TNF + LPS + IFN-γ, mouse and human) cause β-cell damage through the local generation of IL-1 in islets (−20). Overall, these studies begin to define general mechanisms by which tissue macrophage activation may contribute to the loss of β-cell function under conditions associated with type 1 and 2 diabetes.
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