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. 2014 Apr;64(2):105-10.
doi: 10.1007/s13224-013-0487-y. Epub 2013 Dec 1.

Prevalence of overt and subclinical thyroid dysfunction among pregnant women and its effect on maternal and fetal outcome

Sangita Nangia Ajmani  1 , Deepa Aggarwal  2 , Pushpa Bhatia  2 , Manisha Sharma  3 , Vinita Sarabhai  2 , Mohini Paul  2
Affiliations

Prevalence of overt and subclinical thyroid dysfunction among pregnant women and its effect on maternal and fetal outcome

Sangita Nangia Ajmani et al. J Obstet Gynaecol India. 2014 Apr.

Abstract

Aim: To determine the current prevalence of thyroid dysfunction in normal pregnant women and to study the impact of thyroid dysfunction on maternal and fetal outcome.

Methods: 400 pregnant women between 13 and 26 weeks of gestation were registered for the study. Apart from routine obstetrical investigations, TSH tests were done. Free T4 and anti-TPO antibody tests were done in patients with deranged TSH. Patients were followed up till delivery. Their obstetrical and perinatal outcomes were noted.

Results: The prevalence of hypothyroidism and hyperthyroidism was 12 and 1.25 %, respectively. Adverse maternal effects in overt hypothyroidism included preeclampsia (16.6 vs. 7.8 %) and placental abruption (16.6 vs. 0.8 %). Subclinical hypothyroidism was associated with preeclampsia (22.3 vs. 7.8 %) as compared to the euthyroid patients. Adverse fetal outcomes in overt hypothyroidism included spontaneous abortion (16.6 vs. 2.39 %), preterm birth (33.3 vs. 5.8 %), low birth weight (50 vs. 12.11 %), intrauterine growth retardation (25 vs. 4.9 %), and fetal death (16.6 vs. 1.7 %) as compared to the euthyroid women. Adverse fetal outcomes in subclinical hypothyroidism included spontaneous abortion (5.5 vs. 2.39 %), preterm delivery (11.2 vs. 5.8 %), low birth weight (25 vs. 12.11 %), and intrauterine growth retardation (8.4 vs. 4.9 %) as compared to the euthyroid women.

Conclusions: The prevalence of thyroid disorders was high in our study with associated adverse maternal and fetal outcomes. Routine screening of thyroid dysfunction is recommended to prevent adverse fetal and maternal outcome.

Keywords: Fetal outcome; Maternal outcome; Prevalence; Thyroid dysfunction.

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References

    1. Abalovich M, Amino N, Barbour LA, et al. Management of thyroid dysfunction during pregnancy and postpartum: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2007;92(8):1–47. doi: 10.1210/jc.2007-0141. - DOI - PubMed
    1. Negro R, Farmoso G, Mangieri T, et al. Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. J Clin Endocrinol Metab. 2006;91:2587–2591. doi: 10.1210/jc.2005-1603. - DOI - PubMed
    1. Sharma PP, Mukhopadhyay P, Mukhopadhyay A, et al. Hypothyroidism in pregnancy. J Obstet Gynecol India. 2007;57:331–334.
    1. Stagnaro-Green A. Overt hyperthyroidism and hypothyroidism during pregnancy. Clin Obstet Gynecol. 2011;54(3):478–487. doi: 10.1097/GRF.0b013e3182272f32. - DOI - PubMed
    1. Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988–1994): National Health and Nutrition Examination Survey (NHANES III) J Clin Endocrinol Metab. 2002;87(2):489–499. doi: 10.1210/jcem.87.2.8182. - DOI - PubMed

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