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. 1989 May;217(1):168-71.
doi: 10.1007/BF00330957.

Mitochondrial introns aI1 and/or aI2 are needed for the in vivo deletion of intervening sequences

E Levra-Juillet  1 , A Boulet, B Séraphin, M Simon, G Faye
Affiliations

Mitochondrial introns aI1 and/or aI2 are needed for the in vivo deletion of intervening sequences

E Levra-Juillet et al. Mol Gen Genet. 1989 May.

Abstract

Some pet- (or mit-) mutations impeding the splicing of one or several intron(s) of the yeast mitochondrial pre-mRNA(s) are suppressed in vivo by the DNA deletion of these introns. We have genetically demonstrated that introns aI1 and/or aI2 of the cytochrome c oxidase subunit 1 gene are necessary for this deletion process. The facts that adjacent introns are simultaneously deleted and that, in the pet- (or mit-) mutants which easily revert by intron deletion, the splicing of the introns they affect is only partially blocked, suggest that the intron encoded proteins aI1 and/or aI2 could intervene by means of their putative reverse transcriptase activity.

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