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Case Reports
. 1989;415(4):377-82.
doi: 10.1007/BF00718640.

Giant-cell tumor of bone, stage II, displaying translocation t(12;19)(q13;q13)

R Noguera  1 , A Llombart-Bosch, C Lopez-Gines, C Carda, C Fernandez
Affiliations
Case Reports

Giant-cell tumor of bone, stage II, displaying translocation t(12;19)(q13;q13)

R Noguera et al. Virchows Arch A Pathol Anat Histopathol. 1989.

Abstract

A new case of giant-cell tumour (GCT) of bone with benign histological features, clinical stage II, has been reviewed with immunohistochemistry and electron microscopy. After short-term tissue culture the karyotype, using G-banding techniques, presented a consistent translocation t(12;19)(q13;q13). Nude mice xenografts of the tumour were unsuccessful after 6 months of follow-up. Presence of such chromosomal rearrangement may be related to locally aggressive, histologically benign giant-cell tumors of bone.

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