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. 2013 Jul;1(1):27-32.
doi: 10.1093/gastro/got011. Epub 2013 Apr 4.

Autoimmune pancreatitis

Gyanprakash A Ketwaroo  1 , Sunil Sheth
Affiliations

Autoimmune pancreatitis

Gyanprakash A Ketwaroo et al. Gastroenterol Rep (Oxf). 2013 Jul.

Abstract

Autoimmune pancreatitis (AIP) is a rare, heterogeneous, fibroinflammatory disorder of the pancreas. It has gained increasing recognition due to a presentation that can mimic difficult-to-treat disorders such as pancreatic cancer, cholangiocarcinoma and primary sclerosing cholangitis. In contrast, autoimmune pancreatitis is a benign disease that is very responsive to therapy with corticosteroids. There are two types of AIP. Type 1 disease is the most common worldwide and is associated with extrapancreatic manifestations and elevated levels of IgG4-positive cells. Type 2 AIP is characterized by a paucity of IgG4-positive cells and is more difficult to diagnose. This review provides an update on the diagnosis, pathophysiology and treatment of AIP, with special emphasis on the two subtypes.

Keywords: autoimmune pancreatitis; review.

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