Protein stabilization by blocking the native unfolding nucleus
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- PMID: 2476120
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Protein stabilization by blocking the native unfolding nucleus
Biomed Biochim Acta.
1989.
Abstract
Studies on the thermal inactivation of immobilized enzymes result in a novel conception of protein stabilization. The native protein molecule is suggested to be characterized by a specific structural region where the unfolding process starts. Accordingly, enzyme stabilization by immobilization is the result of blocking this unfolding nucleus.
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