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. 1989;48(1):63-7.

Protein stabilization by blocking the native unfolding nucleus

A Schellenberger  1 , R Ulbrich
Affiliations
  • PMID: 2476120

Protein stabilization by blocking the native unfolding nucleus

A Schellenberger et al. Biomed Biochim Acta. 1989.

Abstract

Studies on the thermal inactivation of immobilized enzymes result in a novel conception of protein stabilization. The native protein molecule is suggested to be characterized by a specific structural region where the unfolding process starts. Accordingly, enzyme stabilization by immobilization is the result of blocking this unfolding nucleus.

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