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Comment
. 2014 Apr 24;10(4):e1004315.
doi: 10.1371/journal.pgen.1004315. eCollection 2014 Apr.

The challenges of mitochondrial replacement

Patrick F Chinnery  1 , Lyndsey Craven  2 , Shoukhrat Mitalipov  3 , James B Stewart  4 , Mary Herbert  5 , Douglass M Turnbull  2
Affiliations
Comment

The challenges of mitochondrial replacement

Patrick F Chinnery et al. PLoS Genet. .

Erratum in

  • PLoS Genet. 2014 Jun;10(6):e1004472
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Comment on

References

    1. HFEA, Mitochondria public consultation (2012) Available: http://www.hfea.gov.uk/6896.html. Accessed 29 March 2014.
    1. Koopman WJ, Willems PH, Smeitink JA (2012) Monogenic mitochondrial disorders. N Engl J Med 366: 1132–1141. - PubMed
    1. Wellcome Trust Centre for Mitochondrial Research (2014) Patient Care Guidelines. Available: http://www.newcastle-mitochondria.com/service/patient-care-guidelines/. Accessed 29 March 2014.
    1. Steffann J, Frydman N, Gigarel N, Burlet P, Ray PF, et al. (2006) Analysis of mtDNA variant segregation during early human embryonic development: a tool for successful NARP preimplantation diagnosis. J Med Genet 43: 244–247. - PMC - PubMed
    1. Steffann J, Gigarel N, Corcos J, Bonnière M, Encha-Razavi F, et al. (2007) Stability of the m.8993T→G mtDNA mutation load during human embryofetal development has implications for the feasibility of prenatal diagnosis in NARP syndrome. J Med Genet 44: 664–669. - PMC - PubMed

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