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. 1989 Aug;98(2):93-8.
doi: 10.1007/BF00291043.

5-Azadeoxycytidine induced undercondensation in the giant X chromosomes of Microtus agrestis

T Haaf  1 , M Schmid
Affiliations

5-Azadeoxycytidine induced undercondensation in the giant X chromosomes of Microtus agrestis

T Haaf et al. Chromosoma. 1989 Aug.

Abstract

Fibroblasts of female Microtus agrestis were treated with 5-azadeoxycytidine (5-aza-dCyd) at a final concentration of 10(-5) M during the last 2 h of culture. This cytidine analogue induces distinct undercondensation of the constitutive heterochromatin in the giant X chromosomes. The undercondensed heterochromatic thread exhibits longitudinal segmentation reminiscent of a chromomere pattern. In the late-replicating X chromosome, 5-aza-dCyd also inhibits condensation of the genetically inactivated euchromatin (facultative heterochromatin). The described effects of 5-aza-dCyd on the X chromosome structure appear to be incorporation independent.

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