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Editorial
. 2014 Apr 25;114(9):1362-5.
doi: 10.1161/CIRCRESAHA.114.303786.

Menage a Trois: intimate relationship among a microRNA, long noncoding RNA, and mRNA

Gerald W Dorn 2nd  1 , Scot J Matkovich
Affiliations
Editorial

Menage a Trois: intimate relationship among a microRNA, long noncoding RNA, and mRNA

Gerald W Dorn 2nd et al. Circ Res. .
No abstract available

Keywords: Editorials; RNA; cardiomegaly; microRNAs.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Schematic diagram of miR-499 binding to Sox6 mRNA
An M-fold structure of Sox6 3′UTR is shown with miR-499 binding sites framed in red. These binding domains are enlarged as insets and shown in configurations less favorable (closed) and more favorable (open) for miR-499 seed sequence binding; probability of the more open structure is reported for each as Po. miR-499 is depicted on the open Sox6 configuration in green, with seed sequence in black; RNAhybrid duplex structure and minimum hybridization (binding) energy (BE) is given for each interaction. RNA mass/abundance values determined from publically available adult mouse heart RNA sequencing data are shown as reads/10 million reads.
Figure 2
Figure 2. Schematic diagram of miR-489 binding to lncRNAAK048451 and Myd88 mRNA
M-fold and RNAhybrid structures, Po and BE values, and abundance for the interacting RNA species reported by Wang et al, are depicted as in Figure 1.
See this image and copyright information in PMC

Comment on

References

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