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. 2014 May;7(5):1427-1429.
doi: 10.3892/ol.2014.1954. Epub 2014 Mar 7.

Exophytic gastrointestinal stromal tumor with cystic changes: A case report

Chun-Chao Zhu  1 , Ye Liu  1 , Gang Zhao  1
Affiliations

Exophytic gastrointestinal stromal tumor with cystic changes: A case report

Chun-Chao Zhu et al. Oncol Lett. 2014 May.

Abstract

Gastrointestinal stromal tumor (GIST) is the most common type of mesenchymal tumor in the gastrointestinal tract. A large tumor size often means a poor prognosis. This report presents a case of a large exophytic GIST with cyst change, for which the outcome of favourable prognosis was unexpected. A 78-year-old male presented with abdominal distension and a poor appetite, and was primarily diagnosed with a pancreatic mass. Abdominal ultrasonography, computed tomography and magnetic resonance imaging revealed a tumor in the body of the pancreas, which was closely attached to the gastric wall. Surgery was performed to excise the tumor. The tumor originated from the gastric cells and was ~17×15×16 cm in size. A diagnosis of GIST was confirmed by histomorphological and immunohistochemical findings. According to the postoperative findings, the tumor was classified to be in the high-risk group, for which the suggested treatment is imatinib. However, the patient was not treated with imatinib and, three years following surgery, the patient is alive with no evidence of tumor recurrence.

Keywords: cystic change; exophytic gastrointestinal stromal tumor; prognosis.

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Figures

Figure 1
Figure 1
(A) Magnetic resonance imaging revealed a large cystic-solid mass of 17×15×16 cm in size that had grown into the lesser omental bursa. (B) Coronal plane shows the stomach had changed shape due to compression and the mass was closely attached to the gastric wall.
Figure 2
Figure 2
(A) The resected tumor was a well-circumscribed mass measuring 15×17×13 cm in size. An ulcer was found on the resected gastric wall where it was attached to the tumor. (B) The solid portion of the mass was pink-gray in color and was soft with a scaly appearance.
Figure 3
Figure 3
Microscopically, the tumor cells were epithelioid or spindle-shaped, arranged in an ill-defined fascicular pattern (stain, hematoxylin and eosin; magnification, ×200).
Figure 4
Figure 4
Immunohistochemical analysis revealed that the tumor cells were cluster of differentiation 117-positive (magnification, ×200).
See this image and copyright information in PMC

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