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. 1989 Oct;63(10):4469-73.
doi: 10.1128/JVI.63.10.4469-4473.1989.

Theiler's murine encephalomyelitis virus neutralization escape mutants have a change in disease phenotype

R P Roos  1 , S Stein, M Routbort, A Senkowski, T Bodwell, R Wollmann
Affiliations

Theiler's murine encephalomyelitis virus neutralization escape mutants have a change in disease phenotype

R P Roos et al. J Virol. 1989 Oct.

Abstract

DA strain of Theiler's murine encephalomyelitis virus produces a persistent demyelinating infection. We previously produced escape mutant viruses that are resistant to a neutralizing monoclonal antibody and have a mutation in VP1 amino acid residue 268 in a neutralization site (Y. Ohara, A. Senkowski, J. Fu, L. Klaman, J. Goodall, M. Toth, and R.P. Roos, J. Virol. 62:3527-3529, 1988). In contrast to wild-type DA strain, these escape mutants produce little if any demyelinating disease after inoculation into weanling mice.

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