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Comment
. 2014 Apr 24;157(3):525-7.
doi: 10.1016/j.cell.2014.04.001.

Connect four with glioblastoma stem cell factors

Jan Gronych  1 , Stefan M Pfister  2 , David T W Jones  3
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Connect four with glioblastoma stem cell factors

Jan Gronych et al. Cell. .
Free article

Abstract

Hierarchical cell state models, wherein a few stem-like tumor-propagating cells repopulate the tumor after therapy, are often invoked in cancer. Suvà et al. demonstrate a plastic developmental hierarchy in glioma cell populations by characterizing the epigenetic states of phenotypically distinct cells and identifying four factors sufficient to reprogram differentiated cells into a tumorigenic stem-like state.

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  • Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells.
    Suvà ML, Rheinbay E, Gillespie SM, Patel AP, Wakimoto H, Rabkin SD, Riggi N, Chi AS, Cahill DP, Nahed BV, Curry WT, Martuza RL, Rivera MN, Rossetti N, Kasif S, Beik S, Kadri S, Tirosh I, Wortman I, Shalek AK, Rozenblatt-Rosen O, Regev A, Louis DN, Bernstein BE. Suvà ML, et al. Cell. 2014 Apr 24;157(3):580-94. doi: 10.1016/j.cell.2014.02.030. Epub 2014 Apr 10. Cell. 2014. PMID: 24726434 Free PMC article.