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. 2014 Apr 24;21(4):433-434.
doi: 10.1016/j.chembiol.2014.04.003.

Ready, set, go! How protein kinase C manages dynamic signaling

Robert V Stahelin  1
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Ready, set, go! How protein kinase C manages dynamic signaling

Robert V Stahelin. Chem Biol. .

Abstract

In this issue of Chemistry & Biology, Antal and colleagues describe how phosphorylation optimizes the signaling range of protein kinase C (PKC) isoforms. Priming of these enzymes regulates intramolecular conformational changes, which reduces access to their diacylglycerol (DAG) binding C1 domains.

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