Comment
doi: 10.1016/j.chembiol.2014.04.002.
Targeting mycobacterial proteolytic complexes with natural products
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- PMID: 24766844
- DOI: 10.1016/j.chembiol.2014.04.002
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Comment
Targeting mycobacterial proteolytic complexes with natural products
Chem Biol.
.
Abstract
Controlled proteolysis is key to bacterial viability. In this issue of Chemistry & Biology, Gavrish and colleagues characterize a natural product, lassomycin, targeting the Mycobacterium tuberculosis caseinolytic (Clp) protease. Unusually, lassomycin activates ClpC1, inducing ATPase activity and decoupling it from proteolysis.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Comment on
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Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.Chem Biol. 2014 Apr 24;21(4):509-518. doi: 10.1016/j.chembiol.2014.01.014. Epub 2014 Mar 27. Chem Biol. 2014. PMID: 24684906 Free PMC article.
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