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Comment
. 2014 Apr 24;54(2):208-9.
doi: 10.1016/j.molcel.2014.04.009.

Promiscuity is not always bad

Heng Ru  1 , Pengfei Zhang  1 , Hao Wu  2
Affiliations
Comment

Promiscuity is not always bad

Heng Ru et al. Mol Cell. .

Abstract

In the recent issue of Cell, Bonham et al. (2014) reveal that the sorting adaptor TIRAP regulates the assembly of the Myddosome upon Toll-like receptor activation from both the cell surface and endosomes through its promiscuous binding to lipids.

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Figures

Figure 1
Figure 1. The sorting adaptor TIRAP is required for signaling by both plasma membrane and endosomal TLRs
(A) Schematic image of the unstimulated states with constitutive localization of TIRAP to plasma and endosomal membranes. (B) Upon ligand stimulation, TIRAP at either membranes interacts with activated TLRs and recruits MyD88 through TIR-TIR interaction. (C) Further recruitment of IRAK family kinases leads to the assembly of the Myddosome. (The exact stoichiometry is not inferred in the drawing)
See this image and copyright information in PMC

Comment on

References

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