doi: 10.1073/pnas.86.18.7038.
Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg
Affiliations
- PMID: 2476810
- PMCID: PMC297988
- DOI: 10.1073/pnas.86.18.7038
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Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg
Proc Natl Acad Sci U S A.
1989 Sep.
Abstract
Injection of antisense oligonucleotides was used to investigate the function of c-mos in murine oocytes. Oocytes injected with antisense c-mos oligonucleotides completed the first meiotic division but failed to initiate meiosis II. Instead, loss of c-mos function led to chromosome decondensation, reformation of a nucleus after meiosis I, and cleavage to two cells. Therefore, c-mos is required for meiosis II during murine oocyte maturation.
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