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. 1989 Sep;86(18):7038-42.
doi: 10.1073/pnas.86.18.7038.

Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg

S J O'Keefe  1 , H Wolfes, A A Kiessling, G M Cooper
Affiliations

Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg

S J O'Keefe et al. Proc Natl Acad Sci U S A. 1989 Sep.

Abstract

Injection of antisense oligonucleotides was used to investigate the function of c-mos in murine oocytes. Oocytes injected with antisense c-mos oligonucleotides completed the first meiotic division but failed to initiate meiosis II. Instead, loss of c-mos function led to chromosome decondensation, reformation of a nucleus after meiosis I, and cleavage to two cells. Therefore, c-mos is required for meiosis II during murine oocyte maturation.

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