Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180

Jean Mary Facchini¹, Endi Pricila Alves², Charlise Aguilera³, Regina Maria Miranda Gern⁴, Marcia Luciane Lange Silveira⁵, Elisabeth Wisbeck⁶, Sandra Aparecida Furlan⁷

Affiliations

¹ Master Science in Health and Environment, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
² Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
³ Department of Pharmacy, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
⁴ Master Science in Health and Environment, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Department of Pharmacy, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil. Electronic address: rgern@univille.br.
⁵ Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Department of Pharmacy, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
⁶ Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Master Science in Process Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
⁷ Master Science in Health and Environment, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Master Science in Process Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.

PMID: 24768967
DOI: 10.1016/j.ijbiomac.2014.04.033

Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180

Jean Mary Facchini et al. Int J Biol Macromol. 2014 Jul.

. 2014 Jul:68:72-7.

doi: 10.1016/j.ijbiomac.2014.04.033. Epub 2014 Apr 24.

Authors

Jean Mary Facchini¹, Endi Pricila Alves², Charlise Aguilera³, Regina Maria Miranda Gern⁴, Marcia Luciane Lange Silveira⁵, Elisabeth Wisbeck⁶, Sandra Aparecida Furlan⁷

Affiliations

¹ Master Science in Health and Environment, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
² Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
³ Department of Pharmacy, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
⁴ Master Science in Health and Environment, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Department of Pharmacy, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil. Electronic address: rgern@univille.br.
⁵ Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Department of Pharmacy, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
⁶ Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Master Science in Process Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.
⁷ Master Science in Health and Environment, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Department of Chemical Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil; Master Science in Process Engineering, University of the Region of Joinville - UNIVILLE, Rua Paulo Malschitzki, 10, Campus Universitário, Zona Industrial, Joinville 89.219-710, SC, Brazil.

PMID: 24768967
DOI: 10.1016/j.ijbiomac.2014.04.033

Abstract

The medicinal properties of fungi of the genus Pleurotus have attracted great interest due to their therapeutic properties. Polysaccharides synthesized by Pleurotus, including the β-glucans are considered the main responsible for its therapeutic properties. This study aimed to evaluate the efficacy of polysaccharidic fractions extracted from mycelial biomass of Pleurotus ostreatus DSM 1833 in inhibiting the development of Ehrlich Tumor (ET) and Sarcoma 180 (S-180). FC, FI and FII fractions provided 60.6, 76.5 and 73.6% of ET inhibition, respectively (mean value of about 70%) while FS, FIII-1 and FIII-2 showed no inhibition against ET. FII and FIII-2 resulted in 85.6 and 93.6% (mean value of about 90%) while FIII-1, FC and FS resulted in 54.1 and 0%, respectively, of S-180 inhibition. The yields of the fractions FS, FI, FII, FIII-1 and FIII-2 obtained from P. ostreatus mycelial biomass were 11.6, 1.3, 0.4, 0.65 and 0.35%, respectively. FII fraction (30mg/kg) apparently had no toxic effect on healthy animals, since no difference between the body weights of animals in substance control (SC) and negative control (NC) groups was observed.

Keywords: Ehrlich Tumor; Pleurotus ostreatus; Polysaccharides; Sarcoma 180.

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Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180

Affiliations

Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180

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Abstract

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