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Clinical Trial
. 2014 Jul:765:1-5.
doi: 10.1016/j.mrfmmm.2014.04.006. Epub 2014 Apr 24.

Individual telomere length decay in patients with spondyloarthritis

María Tamayo  1 , Sonia Pértega  2 , Alejandro Mosquera  3 , Montserrat Rodríguez  3 , Francisco J Blanco  4 , José Luis Fernández-Sueiro  4 , Jaime Gosálvez  5 , José Luis Fernández  6
Affiliations
Clinical Trial

Individual telomere length decay in patients with spondyloarthritis

María Tamayo et al. Mutat Res. 2014 Jul.

Abstract

Telomere length was sequentially determined in peripheral blood leukocytes (PBL) from patients with ankylosing spondylitis (AS; n = 44) and psoriatic arthritis (PsA; n = 42) followed through 2.93 ± 0.99 years, using a quantitative PCR (qPCR) assay. The initial telomere size from PsA patients was higher than those with cutaneous psoriasis only (n = 53), possibly due to the inflammatory condition. The qPCR assay was sensitive enough to evidence a significant telomere length shortening in PBL from practically all subjects and PsA patients showed a higher rate of loss of telomere sequence than patients with AS during the follow-up time.

Keywords: Ankylosing spondylitis; Psoriasis; Psoriatic arthritis; Telomere length; qPCR.

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