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Review
. 2014 Apr;66(4):257-67.
doi: 10.1002/iub.1266. Epub 2014 Apr 28.

Functions of volume-sensitive and calcium-activated chloride channels

Else Kay Hoffmann  1 , Niels Bjerre Holm, Ian Henry Lambert
Affiliations
Free article
Review

Functions of volume-sensitive and calcium-activated chloride channels

Else Kay Hoffmann et al. IUBMB Life. 2014 Apr.
Free article

Abstract

The review describes molecular and functional properties of the volume regulated anion channel and Ca(2+)-dependent Cl(-) channels belonging to the anoctamin family with emphasis on physiological importance of these channels in regulation of cell volume, cell migration, cell proliferation, and programmed cell death. Finally, we discuss the role of Cl(-) channels in various diseases.

Keywords: anoctamins; apoptosis; cell migration; proliferation; volume regulated anion channel.

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