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Comment
. 2014 Apr 3:8:31.
doi: 10.3389/fncir.2014.00031. eCollection 2014.

Brain-wide imaging of neurons in action

Erick T Tatro  1
Affiliations
Comment

Brain-wide imaging of neurons in action

Erick T Tatro. Front Neural Circuits. .
No abstract available

Keywords: C. elegans; GFP CalModulin proteins; R. danio; calcium sensor; light-sheet imaging; sculpted light imaging; two-photon imaging; whole brain imaging.

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Figures

Figure 1
Figure 1
(A) Mapping whole brain neural activity is a daunting task, it involves determining how interacting networks respond to stimuli, encode information, and change with development, experience, and aging. Global network interactions of the brain can be described like linkages across continents, with background signaling occurring during resting state, e.g., asynchronous networks as described in Ahrens et al. Upon stimulation, a pathway or node may be activated while suppressing others, changing the global signaling network during and shortly after stimulation. Whole-brain, single-cell resolution, monitoring of activity over time will help to map these networks and nodes. (B) Detecting Ca2+ bursts via fluorescence (δF) in individual neurons brain-wide shows how neuron actions are correlated and anti-correlated at resting state or during stimulus and behavior.
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