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. 2014 Mar;30(2):266-71.

QT dispersion increases with low glomerular filtration rate in patients with coronary artery disease

Murat Celik  1 , Uygarcagdas Yuksel  2 , Yalcin Gokoglan  3 , Baris Bugan  4 , Emre Yalcinkaya  5 , Hilmiumut Unal  6 , Turgay Celik  7 , Atila Iyisoy  8 , Selim Kilic  9
Affiliations

QT dispersion increases with low glomerular filtration rate in patients with coronary artery disease

Murat Celik et al. Pak J Med Sci. 2014 Mar.

Abstract

Objective: We aimed to evaluate the relationship between estimated glomerular filtration rate (eGFR) and QT dispersion (QTd) in patients with coronary artery disease (CAD).

Methods: Sixty patients(mean age 62.72 ± 12.48 years) included 46 male, (mean age 60.89 ± 12.70 years)and 14 female (mean age 68.71± 9.86 years) were enrolled in this study. Patients were divided into 2 groups according to their eGFR using the 6 variable MDRD equation. Group 1 consisted of patients with estimated eGFR<60 ml/min/1.73m(2) and Group 2 consisted of patients witheGFR ≥ 60 ml/min/1.73m(2).

Results: Baseline patient characteristics were homogeneous in both groups except for age, gender and smoking.Also, the extent of CAD was similar in both groups (p > 0.05) QTd values were found higher in group 1 than those of group 2 (57.23 ± 40.65 ms vs. 31.23 ± 14.47 ms, p = 0.002). After adjustment for age, gender and smoking using one-way ANCOVA test, statistically significant difference in QTd still existedbetween the groups (p=0.038).

Conclusion: QTd tends to be higher in patients with poor renal function independent of severity of angiographical CAD. QTd may be a potentially useful non-invasive test in the management of patients with poor renal function, especially those with CAD.

Keywords: Coronary artery disease; Glomerular filtration rate; QT dispersion.

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Figures

Fig.1
Fig.1
QTd values after adjustment for age, sex and smoking using one-way ANCOVA (Analysis of covariance) test
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