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. 2014 Jan;19(1):1-4.
doi: 10.3746/pnf.2014.19.1.001.

Enhancement of Alcohol Metabolism by Sprouted Peanut Extract in SD Rats

Ji Yeon Seo  1 , Seong Soon Kim  2 , Jong-Sang Kim  1
Affiliations

Enhancement of Alcohol Metabolism by Sprouted Peanut Extract in SD Rats

Ji Yeon Seo et al. Prev Nutr Food Sci. 2014 Jan.

Abstract

Excessive ethanol intake is known to induce a number of physiological symptoms, including headache, dizziness and vertigo. In this study, we investigated the attenuation effect of sprouted peanut extract (SPE) on ethanol-induced hangover in male Sprague-Dawley rats. The animals were divided into five groups: the control group, which was administered ethanol only; the ethanol plus SPE experimental groups, which were administered ethanol and 100, 200, or 400 mg SPE/kg b.w.; and the positive control group, which was administered ethanol plus DAWN808(®), a commercial product. SPE-suspended water was delivered to rats via gavage 15 h and 30 min before the administration of ethanol. Blood was collected from the tail 0, 1, 3, and 5 h after ethanol administration. The results showed that serum ethanol concentrations were significantly lower in SPE treated groups than in the control group. Furthermore, hepatic alcohol and acetaldehyde dehydrogenase activities were enhanced by SPE in a dose dependent manner. These results suggest that SPE could be useful in attenuating hangover after alcohol consumption.

Keywords: SD rat; alcohol metabolism; hangover; sprouted peanut.

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Figures

Fig. 1
Fig. 1
Effect of SPE administration on serum ethanol concentrations in ethanol-loaded SD rats. Data were expressed as the means±SD (n=7). a–eMeans with different superscripts are significantly different (P<0.05).
Fig. 2
Fig. 2
Effects of DAWN808® and SPE on hepatic ADH activity in ethanol-loaded SD rats. Data were expressed as the means± SD (n=4). a–gMeans with different superscripts are significantly different (P<0.05).
Fig. 3
Fig. 3
Effect of SPE administration on serum AST activity in ethanol-loaded SD rats. Data were expressed as the means±SD (n=7). a–gMeans with different superscripts are significantly different (P<0.05).
Fig. 4
Fig. 4
Effect of SPE administration on serum ALT activity in ethanol-loaded SD rats. Data were expressed as the means±SD (n=7). a–gMeans with different superscripts are significantly different (P<0.05).
See this image and copyright information in PMC

References

    1. Evans RW, Sun C, Lay C. Alcohol hangover headache. Headache. 2007;47:277–279. - PubMed
    1. Verster JC. The alcohol hangover–a puzzling phenomenon. Alcohol Alcohol. 2008;43:124–126. - PubMed
    1. Prat G, Adan A, Sanchez-Turet M. Alcohol hangover: a critical review of explanatory factors. Hum Psychopharmacol. 2009;24:259–267. - PubMed
    1. Kim WK, Kang NE, Kim MH, Ha AW. Peanut sprout ethanol extract inhibits the adipocyte proliferation, differentiation, and matrix metalloproteinases activities in mouse fibroblast 3T3-L1 preadipocytes. Nutr Res Pract. 2013;7:160–165. - PMC - PubMed
    1. Seo JY, Kim SS, Kim HJ, Liu KH, Lee HY, Kim JS. Laxative effect of peanut sprout extract. Nutr Res Pract. 2013;7:262–266. - PMC - PubMed

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