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Review
. 2014:2014:916542.
doi: 10.1155/2014/916542. Epub 2014 Mar 20.

Estimating glomerular filtration rate in older people

Sabrina Garasto  1 , Sergio Fusco  2 , Francesco Corica  3 , Maria Rosignuolo  1 , Antonio Marino  1 , Alberto Montesanto  4 , Francesco De Rango  4 , Marcello Maggio  5 , Vincenzo Mari  6 , Andrea Corsonello  1 , Fabrizia Lattanzio  7
Affiliations
Review

Estimating glomerular filtration rate in older people

Sabrina Garasto et al. Biomed Res Int. 2014.

Abstract

We aimed at reviewing age-related changes in kidney structure and function, methods for estimating kidney function, and impact of reduced kidney function on geriatric outcomes, as well as the reliability and applicability of equations for estimating glomerular filtration rate (eGFR) in older patients. CKD is associated with different comorbidities and adverse outcomes such as disability and premature death in older populations. Creatinine clearance and other methods for estimating kidney function are not easy to apply in older subjects. Thus, an accurate and reliable method for calculating eGFR would be highly desirable for early detection and management of CKD in this vulnerable population. Equations based on serum creatinine, age, race, and gender have been widely used. However, these equations have their own limitations, and no equation seems better than the other ones in older people. New equations specifically developed for use in older populations, especially those based on serum cystatin C, hold promises. However, further studies are needed to definitely accept them as the reference method to estimate kidney function in older patients in the clinical setting.

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Figures

Figure 1
Figure 1
Summary of age-related changes in kidney structure and function. Data reported from Musso & Oreopoulos, Nephron Physiology 2011.
See this image and copyright information in PMC

References

    1. Astor BC, Matsushita K, Gansevoort RT, et al. Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts. Kidney International. 2011;79(12):1331–1340. - PMC - PubMed
    1. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. The American Journal of Kidney Diseases. 2002;39:S1–S266. - PubMed
    1. Stevens PE, O’Donoghue DJ, De Lusignan S, et al. Chronic kidney disease management in the United Kingdom: NEOERICA project results. Kidney International. 2007;72(1):92–99. - PubMed
    1. Cirillo M, Laurenzi M, Mancini M, Zanchetti A, Lombardi C, De Santo NG. Low glomerular filtration in the population: prevalence, associated disorders, and awareness. Kidney International. 2006;70(4):800–806. - PubMed
    1. Gambaro G, Yabarek T, Graziani MS, et al. Prevalence of CKD in Northeastern Italy: results of the INCIPE study and comparison with NHANES. Clinical Journal of the American Society of Nephrology. 2010;5(11):1946–1953. - PMC - PubMed