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. 1989 Sep;184(1):131-7.
doi: 10.1016/0014-4827(89)90371-6.

The silver-stained proteins of interphasic nucleolar organizer regions as a parameter of cell duplication rate

D Trerè  1 , A Pession, M Derenzini
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The silver-stained proteins of interphasic nucleolar organizer regions as a parameter of cell duplication rate

D Trerè et al. Exp Cell Res. 1989 Sep.

Abstract

The relationship between interphasic silver-stained proteins of the nucleolar organizer regions (Ag-NOR proteins) and cell replication rate has been studied in 13 established neuroblastoma cell lines. The quantity of Ag-NOR proteins was measured in silver-stained cells by means of an automated image analyzer. The results indicated that the amount of Ag-NOR proteins is strictly proportional to the proliferative activity of the cells. Cell lines with a difference of only 4 h in doubling time were characterized by a statistically significant difference in Ag-NOR protein amount. The Ag-NOR protein quantity can therefore be used as a parameter for evaluating the cell proliferation rate.

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