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Case Reports
. 2014 Nov;20(11):O857-60.
doi: 10.1111/1469-0691.12657. Epub 2014 Jun 14.

Bloodstream infections due to Peptoniphilus spp.: report of 15 cases

K Brown  1 , D Church, T Lynch, D Gregson
Affiliations
Free PMC article
Case Reports

Bloodstream infections due to Peptoniphilus spp.: report of 15 cases

K Brown et al. Clin Microbiol Infect. 2014 Nov.
Free PMC article

Abstract

Peptoniphilus spp. are Gram-positive anaerobic cocci (GPAC) that were formerly classified in the genus Peptostreptococcus. This study describes 15 cases of Peptoniphilus spp. bloodstream infection (BSI) diagnosed from 2007 to 2011 using 16S rDNA sequencing in patients with pneumonia, pre-term delivery, soft tissue infection or colon or bladder disease. Seven out of 15 (47%) of these cases had polymicrobial BSIs. One of the isolates was closely related to P. duerdenii (EU526290), while the other 14 isolates were most closely related to a Peptoniphilus sp. reference strain (ATCC 29743) and P. hareii (Y07839). Peptoniphilus is a rare but important cause of BSI.

Keywords: 16S ribosomal DNA sequencing; Anaerobic bacteria; Gram-positive cocci; Peptoniphilus; bacteraemia.

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Figures

Fig 1
Fig 1
Maximum likelihood phylogeny of partial 16S rDNA (variable regions V1–V3) sequences from the Peptoniphilus BSI isolates (GenBank accessions KF963582–KF96396) in relation to publicly available Peptoniphilus reference strains (Genbank accession in parentheses). Fasttree 2 software was used to create the tree using the generalized time-reversible nucleotide substitution model .
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