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. 2014 Apr 28:13:40.
doi: 10.1186/1475-2891-13-40.

Effects of a 3-year dietary intervention on age-related changes in triglyceride and apolipoprotein A-V levels in patients with impaired fasting glucose or new-onset type 2 diabetes as a function of the APOA5 -1131 T > C polymorphism

Minjoo Kim, Jey Sook Chae, Miri Kim, Sang-Hyun Lee, Jong Ho Lee  1
Affiliations

Effects of a 3-year dietary intervention on age-related changes in triglyceride and apolipoprotein A-V levels in patients with impaired fasting glucose or new-onset type 2 diabetes as a function of the APOA5 -1131 T > C polymorphism

Minjoo Kim et al. Nutr J. .

Abstract

Background: The purpose of this study was to estimate the effects of a 3-year dietary intervention on age-related changes in triglyceride and apolipoprotein (apo A-V) levels in patients with impaired fasting glucose (IFG) or new-onset type 2 diabetes as a function of the APOA5 -1131 T > C polymorphism.

Methods: We genotyped the APOA5 -1131 T > C polymorphism in 203 Korean individuals with IFG or new-onset type 2 diabetes for the TT (n = 91), TC (n = 98), and CC (n = 14) alleles. Plasma apo A-V and triglyceride levels were evaluated at baseline and after a 3-year dietary intervention.

Results: Our results showed that HDL, glucose, insulin, HOMA-IR index, free fatty acids, and apo A-V decreased and brachial-ankle pulse wave velocity (ba-PWV) and malondialdehyde (MDA) increased at the 3-year follow-up visit compared with baseline. Plasma apo A-V levels were reduced in subjects with the C allele (TC or CC) (P = 0.036) and triglyceride levels were reduced in subjects with the TT allele (P = 0.047). Subjects with the C allele showed lower post-treatment apo A-V and higher post-treatment fasting triglyceride levels than subjects with the TT allele. Changes in apo A-V and triglyceride levels were negatively correlated in subjects with the TT allele and positively correlated in subjects with the C allele.

Conclusions: This study showed that the dietary intervention prevented an age-related increase in triglyceride levels in individuals with IFG or new-onset type 2 diabetes who possess the TT allele, but not the CT or CC allele, of the APOA5 -1131 T > C polymorphism.

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Figures

Figure 1
Figure 1
Fasting apolipoprotein A-V and triglyceride levels at baseline (white square) and the 3-year follow-up visit (gray square) and mean changes as a function of the APOA5 -1131 T > C genotype. Data (mean ± SE) included 91 (TT), 98 (TC), and 14 (CC) subjects. §Log-transformed. P1, unadjusted P value; P2, baseline-adjusted P value. *P < 0.05 compared with baseline values for each genotype by paired t-test. †P < 0.05 compared with the TT allele; ‡P < 0.05 compared with the TT allele after adjusting for baseline values; #P < 0.05 compared with the TC allele tested by a one-way ANOVA with a Bonferroni correction.
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