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Case Reports
. 2014 Apr 28:2014:bcr2013201941.
doi: 10.1136/bcr-2013-201941.

Herpes zoster encephalopathy or acyclovir neurotoxicity: a management dilemma

Daniel Sacchetti  1 , Aydah Alawadhi, Mustafa Albakour, Alwyn Rapose
Affiliations
Case Reports

Herpes zoster encephalopathy or acyclovir neurotoxicity: a management dilemma

Daniel Sacchetti et al. BMJ Case Rep. .

Abstract

This is a case report of a 69-year-old morbidly obese woman who presented with mental status changes after she was treated with acyclovir for shingles. The predominant symptoms were word-finding difficulties and visual hallucinations. Complicating her presentation was acyclovir-induced acute renal injury causing her creatinine level to rise up to 7.4 mg/dL. Acyclovir was discontinued on the suspicion of acyclovir neurotoxicity. Even though PCR for varicella zoster virus in the cerebrospinal fluid was positive, acyclovir was not restarted and the patient continued to improve and returned to her baseline.

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References

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