Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Jul;92(6):471-2.
doi: 10.1038/icb.2014.36. Epub 2014 Apr 29.

Invariant chain-MHC class II complexes: always odd and never invariant

Peter Cresswell  1 , Paul A Roche  2
Affiliations
Comment

Invariant chain-MHC class II complexes: always odd and never invariant

Peter Cresswell et al. Immunol Cell Biol. 2014 Jul.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Model for the regulation of MHC class II release from the ER by the composition of the Ii trimer. (a) Trimers containing three p35 forms (orange), shown with the N-terminal-extended cytoplasmic domain containing an ER retention signal (black), remain in the ER unless they associate with three MHC class II αβ-dimers (blue). If only one or two αβ-dimers associate, the ‘unblocked’ ER retention sequence(s) remain functional and transport of the complex from the ER is prevented. (b) Trimers containing one, two or three αβ-dimers can leave the ER if all three Ii species are the p33 form (green) that lacks the ER retention signal. (c) A mixed Ii, trimer that contains only one p35 molecule may leave the ER with a single αβ-dimer if the latter associates with p35 and not one of the two p33 molecules also present in the trimer.
See this image and copyright information in PMC

Comment on

References

    1. Blum JS, Wearsch PA, Cresswell P. Pathways of antigen processing. Ann Rev Immunol 2013; 31: 443–473. - PMC - PubMed
    1. Cresswell P. Invariant chain structure and MHC class II function. Cell 1996; 84: 505–507. - PubMed
    1. Marks MS, Blum JS, Cresswell P. Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens. J Cell Biol 1990; 111: 839–855. - PMC - PubMed
    1. Roche PA, Marks MS, Cresswell P. Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain. Nature 1991; 354: 392–394. - PubMed
    1. Lamb CA, Cresswell P. Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes. J Immunol 1992; 148: 3478–3482. - PubMed

MeSH terms