Targeting regulatory T cells in tumor immunotherapy

Mark J Smyth¹, Shin Foong Ngiow², Michele W L Teng³

Affiliations

¹ 1] Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia [2] School of Medicine, University of Queensland, St Lucia, Queensland, Australia.
² Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
³ 1] School of Medicine, University of Queensland, St Lucia, Queensland, Australia [2] Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

PMID: 24777313
DOI: 10.1038/icb.2014.33

Comment

Targeting regulatory T cells in tumor immunotherapy

Mark J Smyth et al. Immunol Cell Biol. 2014 Jul.

. 2014 Jul;92(6):473-4.

doi: 10.1038/icb.2014.33. Epub 2014 Apr 29.

Authors

Mark J Smyth¹, Shin Foong Ngiow², Michele W L Teng³

Affiliations

¹ 1] Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia [2] School of Medicine, University of Queensland, St Lucia, Queensland, Australia.
² Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
³ 1] School of Medicine, University of Queensland, St Lucia, Queensland, Australia [2] Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

PMID: 24777313
DOI: 10.1038/icb.2014.33

No abstract available

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OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy.
Bulliard Y, Jolicoeur R, Zhang J, Dranoff G, Wilson NS, Brogdon JL. Bulliard Y, et al. Immunol Cell Biol. 2014 Jul;92(6):475-80. doi: 10.1038/icb.2014.26. Epub 2014 Apr 15. Immunol Cell Biol. 2014. PMID: 24732076

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Targeting regulatory T cells in tumor immunotherapy

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