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. 2014 Jul;64(1):3-5.
doi: 10.1161/HYPERTENSIONAHA.114.03040. Epub 2014 Apr 28.

Hypertension and dementia

Costantino Iadecola  1
Affiliations

Hypertension and dementia

Costantino Iadecola. Hypertension. 2014 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Potential mechanisms of the cognitive dysfunction induced by hypertension. Hypertension-induced microvascular damage leads to subcortical and periventricular white matter damage (leukoaraiosis), microinfarcts, and microhemorrhages, and may promote amyloid accumulation in brain by impairing the vascular clearance of the Aβ peptide. Hypertension has also been associated with atrophy of the left frontal lobe, a finding that may underlies the alterations in executive function induced by hypertension.
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