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Case Reports
. 2014 Feb 17:5:18.
doi: 10.4103/2152-7806.127257. eCollection 2014.

Giant clival chordoma causing pathological laughter

Daniel Andrade Gripp  1 , Antonio Aversa do Souto  1 , Douglas Gonsales  1 , Marcio de Miranda Chaves Christiani  1 , Janio Nogueira  1 , Helio Ferreira Lopes  1 , Yasmine Coura Torres  1
Affiliations
Case Reports

Giant clival chordoma causing pathological laughter

Daniel Andrade Gripp et al. Surg Neurol Int. .

Abstract

Background: Chordomas are rare slowly growing tumors that originate from remnants of the notochord. They have a malignant local behavior, causing symptoms due to bone infiltration and compression of neurovascular structures. Only a few cases of brain tumors associated with pathological laughter have been reported in the literature.

Case description: We report a case of a 42-year-old male patient with this atypical clinical presentation treated at our institution, and discuss the concerning literature.

Conclusion: Although being a very rare presentation of chordomas, pathological laughter is usually expected to improve after brain stem decompression.

Keywords: Chordoma; clivus; pathological laughter.

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Figures

Figure 1
Figure 1
T1 MRI imaging showing clival lesion, osseous destruction and brain stem displacement
Figure 2
Figure 2
T1 postcontrast MRI imaging showing sphenoid sinus invasion
Figure 3
Figure 3
Postoperative scan showing radical tumor resection
Figure 4
Figure 4
Sagittal postoperative scan showing brain stem decompression
Figure 5
Figure 5
Axial postoperative MRI T1 imaging showing no signs of recurrent tumor
Figure 6
Figure 6
Sagittal MRI T1 imaging showing residual fat and no signs of tumor recurrence
See this image and copyright information in PMC

References

    1. Borba LA, Al-Mefty O, Mark RE, Suen J. Cranial chordomas in children and adolescents. J Neurosurg. 1996;84:584–91. - PubMed
    1. Bhatjiwale MG, Nadkarni TD, Desai KI, Goal A. Pathological laughter as a presenting symptom of massive trigeminal neuromas: Report of four cases. Neurosurgery. 2000;47:469–72. - PubMed
    1. Cascino GD, Andermann F, Berkovic SF, Kuzniecky RI, Sharbrough FW, Keene DL, et al. Gelastic seizures and hypothalamic hamartomas. Evaluation of patients undergoing chronic intracranial EEG monitoring and outcome of surgical treatment. Neurology. 1993;43:747–50. - PubMed
    1. Garg RK, Misra S, Verma R. Pathological laughter as heralding manifestation of left middle cerebral artery territory infarct: Case report and review of literature. Neurol India. 2000;48:388–90. - PubMed
    1. Matsuoka S, Yokota A, Yasukouchi H, Harada A, Kadoya C, Wada S, et al. Clival chordoma associated with pathological laughter. Case report. J Neurosurg. 1993;79:428–33. - PubMed

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