Sudden sensorineural hearing loss influence of hemodynamical and hemorheological factors on spontaneous recovery and therapy results

Abstract

The effect of a hemodilution therapy for sudden sensorineural hearing loss was analysed comparing the results of a prospective randomised double blind study and a retrospective study at the Frankfurt university. The prospective study consists of a treatment group receiving infusions with hydroxyethyl starch-pentoxifyllin and a control group with infusions with normal saline. Another patient group receiving hydroxyethyl starch-pentoxifyllin-naftidrofuryl infusions was analysed retrospectively. The overall therapy results are in the same range for all 3 groups. However patients with a hemoglobin value above 14 mg % in the control group had a poorer result compared to the other groups. The patient group with systolic blood pressure above 130 mm Hg treated with hydroxyethyl starch-pentoxifyllin had a significant hearing improvement over normal saline and hydroxyethyl starch-pentoxifyllin-naftidrofuryl. With increasing systolic blood pressure, patients in the control and hydroxyethyl starch-pentoxifyllin-naftidrofuryl groups had a statistically significant lower therapy result.