doi: 10.1016/0002-9378(89)90787-4.
A monoclonal antibody (MSN-1) against a newly established uterine endometrial cancer cell line (SNG-II) and its application to immunohistochemistry and flow cytometry
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- PMID: 2478021
- DOI: 10.1016/0002-9378(89)90787-4
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A monoclonal antibody (MSN-1) against a newly established uterine endometrial cancer cell line (SNG-II) and its application to immunohistochemistry and flow cytometry
Am J Obstet Gynecol.
1989 Oct.
Abstract
To determine a phenotypic difference between normal endometrium and endometrial adenocarcinoma, a new monoclonal antibody (MSN-1) was produced by immunizing a new endometrial cancer cell line (SNG-II), which was established in 1981 from a 43-year-old Japanese woman with stage II uterine endometrial cancer. MSN-1 recognized the Lewis-b carbohydrate moiety on the cell surface glycolipid and seldom reacted immunohistochemically with normal endometrium but with about 90% of endometrial cancer cases. By application of MSN-1 to flow cytometry, the possibility of differentiating endometrial normal cells from cancer cells was demonstrated.
Comment in
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Flow cytometric quantitation of tumor-associated antigens in solid tumors.Am J Obstet Gynecol. 1990 Aug;163(2):698-9. doi: 10.1016/0002-9378(90)91265-e. Am J Obstet Gynecol. 1990. PMID: 2386176 No abstract available.
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