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. 1989 Oct;161(4):1079-86.
doi: 10.1016/0002-9378(89)90787-4.

A monoclonal antibody (MSN-1) against a newly established uterine endometrial cancer cell line (SNG-II) and its application to immunohistochemistry and flow cytometry

S Nozawa  1 , M Sakayori, K Ohta, R Iizuka, H Mochizuki, M Soma, J Fujimoto, J Hata, M Iwamori, Y Nagai
Affiliations

A monoclonal antibody (MSN-1) against a newly established uterine endometrial cancer cell line (SNG-II) and its application to immunohistochemistry and flow cytometry

S Nozawa et al. Am J Obstet Gynecol. 1989 Oct.

Abstract

To determine a phenotypic difference between normal endometrium and endometrial adenocarcinoma, a new monoclonal antibody (MSN-1) was produced by immunizing a new endometrial cancer cell line (SNG-II), which was established in 1981 from a 43-year-old Japanese woman with stage II uterine endometrial cancer. MSN-1 recognized the Lewis-b carbohydrate moiety on the cell surface glycolipid and seldom reacted immunohistochemically with normal endometrium but with about 90% of endometrial cancer cases. By application of MSN-1 to flow cytometry, the possibility of differentiating endometrial normal cells from cancer cells was demonstrated.

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